IDH3A

Across TCGA patient cohorts, IDH3A mutation is significantly associated with the RNA expression of many other genes, with 855 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDH3A-associated genes across cancer lineages are RNU6-543P, RNU2-47P, and RNA5SP222. Each is linked with IDH3A in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH3A-to-partner and partner-to-IDH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-543P grouped by IDH3A-low versus IDH3A-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH3A→partner) and Y-score (partner→IDH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-543P →	+0.283	+8.055	<.001	.007	3	2
BRCA	RNU2-47P →	+0.628	+8.055	<.001	.007	3	2
BRCA	RNA5SP222 →	+0.286	+7.731	<.001	.009	3	2
UCEC	TRAJ28 →	+0.501	+2.302	.002	.005	3	2
UCEC	LINC00363 →	+0.154	+3.705	<.001	<.001	3	2
UCEC	CYFIP1 →	+0.749	+3.483	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 855 associations by consensus.

RNU6-543P by IDH3A expression — BRCA

Explore this box plot interactively →