IDH3A

Across TCGA patient cohorts, IDH3A mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDH3A-associated genes across cancer lineages are 14-3-3_beta, ERK2, and Akt_pS473. Each is linked with IDH3A in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH3A-to-partner and partner-to-IDH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IDH3A-low versus IDH3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH3A→partner) and Y-score (partner→IDH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.141	-3.446	.005	.005	3	1
UCEC	ERK2 →	+0.208	+3.000	.031	.036	3	1
UCEC	Akt_pS473 →	+0.825	+2.321	.021	.035	3	1
UCEC	Akt_pT308 →	+0.639	+2.321	.043	.035	3	1
UCEC	PRAS40_pT246 →	+0.230	+2.335	.007	.020	3	1
UCEC	Tuberin_pT1462 →	+0.354	+2.331	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

14-3-3_beta by IDH3A expression — UCEC

Explore this box plot interactively →