IDH3A

Across TCGA cell cohorts, IDH3A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,625 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IDH3A-associated GO terms across cancer lineages are Regulation of cell cycle checkpoint, Regulation of mitotic spindle checkpoint, and Regulation of spindle checkpoint. Each is linked with IDH3A in more than 13 cancer types. Because this analysis shows association rather than direction, both IDH3A-to-partner and partner-to-IDH3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell cycle checkpoint grouped by IDH3A-low versus IDH3A-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH3A→partner) and Y-score (partner→IDH3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle checkpoint →	+0.102	+0.937	<.001	<.001	3	14
CNS	Regulation of mitotic spindle checkpoint →	+0.110	+0.596	<.001	.005	3	13
CNS	Regulation of spindle checkpoint →	+0.111	+0.589	<.001	.004	3	13
CNS	Regulation of mitotic cell cycle spindle assembly checkpoint →	+0.110	+0.596	<.001	.005	3	13
UPPER_AERODIGESTIVE_TRACT	Sister chromatid cohesion →	+0.093	+1.020	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.133	+1.093	.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,625 associations by consensus.

Regulation of cell cycle checkpoint by IDH3A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →