IDH2

Across TCGA pan-cancer cohorts, IDH2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IDH2 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher IDH2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IDH2 expression acts as an unfavorable survival marker, although some lineages such as LGG show a favorable association.

BLCA, UCEC, and SKCM are the cancer types where IDH2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.051	0.720	<.001	48	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	All	0.130	0.737	.003	6	view →
LGG	DFS	Median	All	1.000	0.726	.012	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IDH2–BLCA (OS)

Open the BLCA breakdown →