IDH2

Across TCGA patient cohorts, IDH2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,433 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IDH2-associated proteins across cancer lineages are VIM, PRC1_T481, and CLUH. Each is linked with IDH2 in more than 4 cancer types. Because this analysis shows association rather than direction, both IDH2-to-partner and partner-to-IDH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IDH2 versus VIM in GBM, with a Pearson correlation of -0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH2→partner) and Y-score (partner→IDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VIM →	-0.481	-0.397	<.001	<.001	3	5
PDAC	PRC1_T481 →	+1.127	+0.427	<.001	<.001	3	5
BRCA	CLUH →	+0.318	+0.657	.001	<.001	3	5
CCRCC	QSOX1_S426 →	-0.968	-0.488	.005	.001	3	4
UCEC	KCTD12 →	-0.685	-0.992	<.001	.001	3	4
LUAD	ARHGAP17 →	-0.189	-0.608	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,433 associations by consensus.

IDH2 vs VIM — GBM

Explore this scatter interactively →