IDH2

Across TCGA patient cohorts, IDH2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,082 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IDH2-associated genes across cancer lineages are ZNF710-AS1, APOO, and IDH2-DT. Each is linked with IDH2 in more than 5 cancer types. Because this analysis shows association rather than direction, both IDH2-to-partner and partner-to-IDH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IDH2 versus ZNF710-AS1 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH2→partner) and Y-score (partner→IDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF710-AS1 →	+0.789	+0.551	<.001	<.001	3	6
OV	APOO →	+0.561	+0.558	.002	.002	3	5
GBM	IDH2-DT →	+0.824	+0.439	<.001	<.001	3	5
LUAD	GPT2 →	+0.941	+0.487	<.001	<.001	3	5
OV	SFXN3 →	-0.594	-0.601	.008	.001	3	4
OV	HSPA12B →	-0.873	-0.535	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,082 associations by consensus.

IDH2 vs ZNF710-AS1 — BRCA

Explore this scatter interactively →