IDH2

Across TCGA patient cohorts, IDH2 mutation is significantly associated with the RNA expression of many other genes, with 4,940 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDH2-associated genes across cancer lineages are LINC01078, FCGBP, and RNU6-166P. Each is linked with IDH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IDH2-to-partner and partner-to-IDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01078 grouped by IDH2-low versus IDH2-high in LAML.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH2→partner) and Y-score (partner→IDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	LINC01078 →	+0.135	+3.632	<.001	.002	3	2
LGG	FCGBP →	-1.506	-3.584	<.001	.002	3	2
BLCA	RNU6-166P →	+0.343	+7.640	<.001	.009	3	2
UCEC	USP42 →	+0.470	+3.354	.002	.005	3	2
UCEC	AP1S1 →	+0.466	+2.513	.001	.001	3	2
UCEC	STAG3L4 →	+0.804	+3.021	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,940 associations by consensus.

LINC01078 by IDH2 expression — LAML

Explore this box plot interactively →