IDH2

Across TCGA patient cohorts, IDH2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IDH2-associated genes across cancer lineages are Ku80, CD49b, and Syk. Each is linked with IDH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH2-to-partner and partner-to-IDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by IDH2-low versus IDH2-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH2→partner) and Y-score (partner→IDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Ku80 →	+0.317	+2.006	.003	.018	3	2
UCEC	CD49b →	-0.379	-2.308	.003	.033	3	2
LGG	Syk →	-0.280	-3.800	.049	<.001	3	1
LGG	AR →	-0.136	-3.000	.029	.036	3	1
LGG	Beclin →	+0.078	+2.848	.043	.033	3	1
LGG	Chk1_pS345 →	-0.133	-2.574	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Ku80 by IDH2 expression — LGG

Explore this box plot interactively →