IDH2

Across TCGA cell cohorts, IDH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,870 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IDH2-associated GO terms across cancer lineages are Negative regulation of glial cell migration, Regulation of matrix metallopeptidase secretion, and Isocitrate metabolic process. Each is linked with IDH2 in more than 19 cancer types. Because this analysis shows association rather than direction, both IDH2-to-partner and partner-to-IDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of glial cell migration grouped by IDH2-low versus IDH2-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH2→partner) and Y-score (partner→IDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Negative regulation of glial cell migration →	+0.264	+1.612	<.001	<.001	3	20
BONE	Regulation of matrix metallopeptidase secretion →	+0.276	+1.041	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Isocitrate metabolic process →	+0.171	+1.356	<.001	<.001	3	16
LUNG_NSCLC_LUAD	Tricarboxylic acid metabolic process →	+0.168	+1.490	<.001	<.001	3	16
BLOOD_Myeloma	NADP+ biosynthetic process →	+0.170	+2.836	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Tricarboxylic acid cycle →	+0.148	+1.816	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,870 associations by consensus.

Negative regulation of glial cell migration by IDH2 expression — CNS

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