IDH2

Across TCGA cell cohorts, IDH2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IDH2-associated genes across cancer lineages are KCNA4, OR2L5, and TEX53. Each is linked with IDH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH2-to-partner and partner-to-IDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA4 grouped by IDH2-low versus IDH2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH2→partner) and Y-score (partner→IDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNA4 →	+0.028	+4.922	<.001	.009	3	1
STOMACH	OR2L5 →	+0.019	+3.794	<.001	.003	3	1
STOMACH	TEX53 →	+0.082	+4.280	<.001	.001	3	1
LARGE_INTESTINE	GRM4 →	+1.019	+3.491	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.009	+3.240	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KCNA4 by IDH2 expression — BLOOD_Leukemia

Explore this box plot interactively →