IDH1

Across TCGA pan-cancer cohorts, IDH1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated IDH1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher IDH1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated IDH1 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCEC show a favorable association.

LGG, UCEC, and BLCA are the cancer types where IDH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.883	0.602	<.001	18	view →
UCEC	DFS	Median	II,III,IV	1.000	0.441	.025	14	view →
BLCA	OS	Median	IV	0.018	0.600	<.001	12	view →
CHOL	DFS	Median	All	0.106	0.528	.005	9	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	7	view →
GBM	DFS	Median	All	0.588	0.185	.009	6	view →
PRAD	DFS	Median	All	0.725	0.935	.008	6	view →
LIHC	OS	Median	III,IV	0.094	0.615	<.001	3	view →
BRCA	DFS	Median	All	0.160	0.526	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IDH1–LGG (OS)

Open the LGG breakdown →