IDH1

Across TCGA pan-cancer cohorts, IDH1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IDH1 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IDH1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IDH1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, GBM, and UCEC are the cancer types where IDH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.640	0.444	<.001	46	view →
GBM	OS	Quartile	All	0.310	0.695	.009	11	view →
UCEC	OS	Median	All	0.982	0.857	.016	8	view →
HNSC	DFS	Quartile	All	0.927	1.000	.029	6	view →
LSCC	OS	Median	II,III,IV	1.000	0.909	.026	2	view →
CCRCC	OS	Median	All	0.847	0.952	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IDH1–PDAC (OS)

Open the PDAC breakdown →