IDH1

Across TCGA cell cohorts, IDH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,143 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IDH1-associated GO terms across cancer lineages are 2-oxoglutarate metabolic process, Cellular response to toxic substance, and Organic acid catabolic process. Each is linked with IDH1 in more than 13 cancer types. Because this analysis shows association rather than direction, both IDH1-to-partner and partner-to-IDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 2-oxoglutarate metabolic process grouped by IDH1-low versus IDH1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH1→partner) and Y-score (partner→IDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	2-oxoglutarate metabolic process →	+0.126	+1.678	.002	.002	2	14
LIVER	Cellular response to toxic substance →	+0.118	+1.392	<.001	<.001	3	12
LARGE_INTESTINE	Organic acid catabolic process →	+0.070	+1.243	<.001	<.001	3	12
LARGE_INTESTINE	Carboxylic acid catabolic process →	+0.070	+1.243	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Negative regulation of ferroptosis →	+0.223	+1.378	<.001	.004	3	11
LIVER	Secondary alcohol metabolic process →	+0.118	+1.348	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,143 associations by consensus.

2-oxoglutarate metabolic process by IDH1 expression — LIVER

Explore this box plot interactively →