IDH1

Across TCGA cell cohorts, IDH1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IDH1-associated genes across cancer lineages are CDH20, ULBP3, and HRK. Each is linked with IDH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IDH1-to-partner and partner-to-IDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH20 grouped by IDH1-low versus IDH1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IDH1→partner) and Y-score (partner→IDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH20 →	+0.112	+3.222	<.001	.002	3	1
LARGE_INTESTINE	ULBP3 →	+1.059	+3.064	<.001	.009	3	1
LARGE_INTESTINE	HRK →	+0.584	+3.241	.001	.007	3	1
LARGE_INTESTINE	RIPK1 →	+0.646	+3.201	.003	.006	3	1
LARGE_INTESTINE	RASGEF1C →	+0.206	+3.626	.003	.001	3	1
LARGE_INTESTINE	SUV39H2 →	+0.764	+3.067	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

CDH20 by IDH1 expression — LARGE_INTESTINE

Explore this box plot interactively →