ID3

Across TCGA patient cohorts, ID3 mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ID3-associated genes across cancer lineages are RNU6-1205P, RNU6-280P, and MIR4682. Each is linked with ID3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ID3-to-partner and partner-to-ID3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1205P grouped by ID3-low versus ID3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ID3→partner) and Y-score (partner→ID3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1205P →	+0.562	+3.105	<.001	.005	3	2
UCEC	RNU6-280P →	+0.266	+4.660	<.001	.003	3	2
UCEC	MIR4682 →	+0.747	+3.526	<.001	.001	3	1
UCEC	MIR5697 →	+0.627	+2.888	<.001	.008	3	1
UCEC	LINC01387 →	+0.289	+2.815	<.001	.008	3	1
UCEC	MIR5091 →	+0.859	+3.093	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

RNU6-1205P by ID3 expression — UCEC

Explore this box plot interactively →