ID3

Across TCGA cell cohorts, ID3 mutation is significantly associated with the RNA expression of many other genes, with 539 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ID3-associated genes across cancer lineages are SRRD, RBFOX2, and TAB1. Each is linked with ID3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ID3-to-partner and partner-to-ID3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRRD grouped by ID3-low versus ID3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ID3→partner) and Y-score (partner→ID3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SRRD →	+1.079	+3.459	<.001	.003	3	1
BLOOD_Lymphoma	RBFOX2 →	+2.115	+3.459	<.001	.003	3	1
BLOOD_Lymphoma	TAB1 →	+0.515	+3.224	.007	.005	3	1
BLOOD_Lymphoma	IL2RB →	-2.747	-3.321	.006	.004	3	1
BLOOD_Lymphoma	ZNF516 →	+1.149	+3.459	.005	.003	3	1
BLOOD_Lymphoma	TIMP1 →	-3.089	-3.459	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 539 associations by consensus.

SRRD by ID3 expression — BLOOD_Lymphoma

Explore this box plot interactively →