ID2

Across TCGA patient cohorts, ID2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ID2-associated genes across cancer lineages are GAPDH, ERK2, and JNK2. Each is linked with ID2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ID2-to-partner and partner-to-ID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ID2-low versus ID2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ID2→partner) and Y-score (partner→ID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.652	+3.000	.026	.036	3	1
UCEC	ERK2 →	+0.226	+3.000	.032	.036	2	1
UCEC	JNK2 →	+0.355	+3.169	.001	.020	2	1
UCEC	MEK1 →	+0.537	+3.169	.007	.020	2	1
UCEC	eIF4E →	+0.269	+3.169	.020	.020	1	1
UCEC	p62 Lck ligand →	+0.609	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

GAPDH by ID2 expression — UCEC

Explore this box plot interactively →