ICOS

Across TCGA pan-cancer cohorts, ICOS Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ICOS data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher ICOS Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ICOS expression acts as an unfavorable survival marker.

LUSC, COAD, and LIHC are the cancer types where ICOS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.505	0.743	<.001	15	view →
COAD	OS	Median	All	0.168	0.806	.002	12	view →
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ICOS–LUSC (OS)

Open the LUSC breakdown →