ICOS

Across TCGA patient cohorts, ICOS protein abundance is significantly associated with the RNA expression of many other genes, with 4,367 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ICOS-associated genes across cancer lineages are IL2RB, IL21R, and IL4I1. Each is linked with ICOS in more than 3 cancer types. Because this analysis shows association rather than direction, both ICOS-to-partner and partner-to-ICOS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ICOS versus IL2RB in LUAD, with a Pearson correlation of 0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICOS→partner) and Y-score (partner→ICOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IL2RB →	+2.095	+0.901	<.001	.008	3	4
LUAD	IL21R →	+1.893	+1.045	<.001	.002	3	4
LUAD	IL4I1 →	+2.543	+1.005	<.001	.002	3	4
HNSC	SPOCK2 →	+1.987	+0.809	<.001	<.001	3	4
HNSC	ZAP70 →	+2.006	+0.934	<.001	.001	3	4
HNSC	CD2 →	+2.637	+0.931	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,367 associations by consensus.

ICOS vs IL2RB — LUAD

Explore this scatter interactively →