ICOS

Across TCGA patient cohorts, ICOS mutation is significantly associated with the RNA expression of many other genes, with 367 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICOS-associated genes across cancer lineages are BTBD10, NCAPD3, and SLC25A4. Each is linked with ICOS in more than 1 cancer types. Because this analysis shows association rather than direction, both ICOS-to-partner and partner-to-ICOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTBD10 grouped by ICOS-low versus ICOS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICOS→partner) and Y-score (partner→ICOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTBD10 →	+0.580	+3.337	.005	.005	3	1
UCEC	NCAPD3 →	+0.723	+3.470	.004	.003	3	1
UCEC	SLC25A4 →	+0.578	+3.470	.009	.003	3	1
UCEC	BUB3 →	+0.548	+3.245	.004	.008	3	1
UCEC	VPS37A →	+0.711	+3.470	.001	.003	3	1
UCEC	C9orf43 →	+0.399	+3.234	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 367 associations by consensus.

BTBD10 by ICOS expression — UCEC

Explore this box plot interactively →