ICOS

Across TCGA patient cohorts, ICOS mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICOS-associated genes across cancer lineages are MEP, pDC, and Erythrocytes. Each is linked with ICOS in more than 1 cancer types. Because this analysis shows association rather than direction, both ICOS-to-partner and partner-to-ICOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEP grouped by ICOS-low versus ICOS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICOS→partner) and Y-score (partner→ICOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEP →	+0.042	+3.470	.002	.003	3	1
UCEC	pDC →	+0.057	+3.008	.018	.019	3	1
UCEC	Erythrocytes →	+0.025	+3.071	.044	.017	2	1
UCEC	lymphatic Endothelial cells →	-0.027	-3.281	.023	.010	2	1
UCEC	mv Endothelial cells →	-0.031	-2.311	.008	.036	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEP by ICOS expression — UCEC

Explore this box plot interactively →