ICOS

Across TCGA cell cohorts, ICOS RNA expression is significantly associated with the go_rna of many other GO terms, with 1,935 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICOS-associated GO terms across cancer lineages are Positive regulation of defense response to bacterium, Mitochondrion-endoplasmic reticulum membrane tethering, and Homologous recombination. Each is linked with ICOS in more than 4 cancer types. Because this analysis shows association rather than direction, both ICOS-to-partner and partner-to-ICOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of defense response to bacterium grouped by ICOS-low versus ICOS-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICOS→partner) and Y-score (partner→ICOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of defense response to bacterium →	-0.176	-0.792	<.001	.009	3	5
SKIN	Mitochondrion-endoplasmic reticulum membrane tethering →	+0.097	+0.717	<.001	.002	3	4
LIVER	Homologous recombination →	+0.085	+0.006	<.001	.005	3	4
BLOOD_Lymphoma	Late endosome to vacuole transport via multivesicular body sorting pathway →	+0.046	+1.103	<.001	.008	3	4
BLOOD_Lymphoma	Regulation of angiogenesis →	-0.031	-1.475	.002	.002	3	4
SKIN	Renal tubule development →	-0.057	-0.744	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,935 associations by consensus.

Positive regulation of defense response to bacterium by ICOS expression — BLOOD_Lymphoma

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