ICOS

Across TCGA cell cohorts, ICOS mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ICOS-associated genes across cancer lineages are MS4A10. Each is linked with ICOS in more than 1 cancer types. Because this analysis shows association rather than direction, both ICOS-to-partner and partner-to-ICOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A10 grouped by ICOS-low versus ICOS-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICOS→partner) and Y-score (partner→ICOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

MS4A10 by ICOS expression — OVARY

Explore this box plot interactively →