ICMT

Across TCGA patient cohorts, ICMT RNA expression is significantly associated with the protein abundance of many other proteins, with 10,677 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ICMT-associated proteins across cancer lineages are ARHGEF16, ENO1, and RPL22L1_S118. Each is linked with ICMT in more than 5 cancer types. Because this analysis shows association rather than direction, both ICMT-to-partner and partner-to-ICMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ICMT versus ARHGEF16 in LUAD, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ICMT→partner) and Y-score (partner→ICMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARHGEF16 →	+0.403	+0.521	<.001	<.001	3	6
OV	ENO1 →	+0.320	+0.490	<.001	<.001	3	5
LUAD	RPL22L1_S118 →	-0.653	-0.442	<.001	<.001	3	5
OV	LUZP1 →	+0.415	+0.566	<.001	<.001	3	5
COAD	MAPK6_S189 →	+0.598	+0.444	<.001	.003	3	5
LUAD	CDKN1B →	-0.447	-0.418	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,677 associations by consensus.

ICMT vs ARHGEF16 — LUAD

Explore this scatter interactively →