ICMT

Across TCGA patient cohorts, ICMT protein abundance is significantly associated with the RNA expression of many other genes, with 9,032 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ICMT-associated genes across cancer lineages are B3GALT6, GNB1, and LRRC47. Each is linked with ICMT in more than 4 cancer types. Because this analysis shows association rather than direction, both ICMT-to-partner and partner-to-ICMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ICMT versus B3GALT6 in OV, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICMT→partner) and Y-score (partner→ICMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	B3GALT6 →	+0.604	+0.488	<.001	.004	3	5
HNSC	GNB1 →	+0.438	+0.324	.004	.007	3	5
OV	LRRC47 →	+0.573	+0.582	.001	<.001	3	4
OV	PGD →	+0.638	+0.437	<.001	.001	3	4
OV	NOL9 →	+0.692	+0.410	.003	.003	3	4
OV	CPTP →	+0.730	+0.610	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,032 associations by consensus.

ICMT vs B3GALT6 — OV

Explore this scatter interactively →