ICMT

Across TCGA patient cohorts, ICMT mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICMT-associated genes across cancer lineages are Ku80, Annexin-1, and Shc_pY317. Each is linked with ICMT in more than 1 cancer types. Because this analysis shows association rather than direction, both ICMT-to-partner and partner-to-ICMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ICMT-low versus ICMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICMT→partner) and Y-score (partner→ICMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.214	+1.335	.018	.046	3	2
UCEC	Annexin-1 →	+0.732	+2.584	<.001	.010	3	2
UCEC	Shc_pY317 →	-0.175	-2.000	.002	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.556	+2.479	.014	.010	3	2
UCEC	14-3-3_beta →	-0.097	-2.432	.011	.018	3	1
UCEC	eIF4G →	+0.347	+2.807	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Ku80 by ICMT expression — UCEC

Explore this box plot interactively →