ICMT

Across TCGA cell cohorts, ICMT RNA expression is significantly associated with the RNA expression of many other genes, with 10,933 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICMT-associated genes across cancer lineages are CLSPN, CENPI, and GNB1. Each is linked with ICMT in more than 18 cancer types. Because this analysis shows association rather than direction, both ICMT-to-partner and partner-to-ICMT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ICMT versus CLSPN in URINARY_TRACT, with a Pearson correlation of 0.69.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICMT→partner) and Y-score (partner→ICMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CLSPN →	+2.031	+0.772	<.001	.002	3	19
UPPER_AERODIGESTIVE_TRACT	CENPI →	+1.619	+1.102	<.001	<.001	2	18
BREAST	GNB1 →	+1.159	+1.093	<.001	<.001	3	17
SOFT_TISSUE	DNAJC11 →	+1.177	+0.814	<.001	.001	3	17
KIDNEY	MFN2 →	+1.351	+1.054	<.001	<.001	3	17
BREAST	SZRD1 →	+1.128	+0.874	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,933 associations by consensus.

ICMT vs CLSPN — URINARY_TRACT

Explore this scatter interactively →