ICMT

Across TCGA cell cohorts, ICMT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,914 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICMT-associated GO terms across cancer lineages are Positive regulation of chromosome segregation, Regulation of cell cycle checkpoint, and Regulation of chromosome segregation. Each is linked with ICMT in more than 16 cancer types. Because this analysis shows association rather than direction, both ICMT-to-partner and partner-to-ICMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome segregation grouped by ICMT-low versus ICMT-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICMT→partner) and Y-score (partner→ICMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of chromosome segregation →	+0.234	+1.178	<.001	<.001	3	17
OESOPHAGUS	Regulation of cell cycle checkpoint →	+0.165	+1.158	<.001	<.001	3	17
OESOPHAGUS	Regulation of chromosome segregation →	+0.163	+1.011	<.001	.001	3	16
OESOPHAGUS	Mitotic chromosome condensation →	+0.243	+1.076	<.001	<.001	3	16
OESOPHAGUS	Nuclear chromosome segregation →	+0.150	+1.176	.001	<.001	3	16
OESOPHAGUS	Regulation of mitotic spindle checkpoint →	+0.167	+1.057	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,914 associations by consensus.

Positive regulation of chromosome segregation by ICMT expression — OESOPHAGUS

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