ICE2P1

Across TCGA pan-cancer cohorts, ICE2P1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated ICE2P1 data layer.

The strongest signal is observed in pheochromocytoma and paraganglioma (PCPG), where higher ICE2P1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ICE2P1 expression acts as an unfavorable survival marker, although some lineages such as SARC show a favorable association.

PCPG, HNSC, and BLCA are the cancer types where ICE2P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PCPG	DFS	Tertile	All	0.411	0.854	.007	27	view →
HNSC	DFS	Tertile	All	0.236	0.346	.026	21	view →
BLCA	DFS	Tertile	All	0.410	0.614	.049	18	view →
MESO	DFS	Quartile	IV	0.117	0.348	.033	18	view →
SKCM	OS	Tertile	IV	0.253	0.666	.011	18	view →
COAD	OS	Tertile	IV	0.190	0.699	.018	18	view →
READ	OS	Tertile	III,IV	0.724	0.943	.025	9	view →
SARC	DFS	Tertile	All	0.835	0.602	.045	3	view →
KIRC	OS	Median	All	0.770	0.832	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ICE2P1–PCPG (DFS)

Open the PCPG breakdown →