ICE2

Across TCGA patient cohorts, ICE2 mutation is significantly associated with the RNA expression of many other genes, with 4,949 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICE2-associated genes across cancer lineages are LINC02146, MIR5696, and RNA5SP503. Each is linked with ICE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ICE2-to-partner and partner-to-ICE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02146 grouped by ICE2-low versus ICE2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICE2→partner) and Y-score (partner→ICE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	LINC02146 →	+0.263	+4.646	.001	.004	3	3
BRCA	MIR5696 →	+0.557	+5.440	<.001	<.001	3	2
LUAD	RNA5SP503 →	+0.494	+4.730	<.001	.005	3	2
UCEC	KIAA0930 →	+0.319	+2.130	.001	.002	3	2
UCEC	CCDC22 →	+0.306	+1.523	.002	<.001	3	2
UCEC	UBL4A →	+0.284	+1.680	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,949 associations by consensus.

LINC02146 by ICE2 expression — STAD

Explore this box plot interactively →