ICE2

Across TCGA cell cohorts, ICE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,972 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICE2-associated GO terms across cancer lineages are Recombinational repair, Regulation of heterochromatin organization, and Protein sumoylation. Each is linked with ICE2 in more than 14 cancer types. Because this analysis shows association rather than direction, both ICE2-to-partner and partner-to-ICE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Recombinational repair grouped by ICE2-low versus ICE2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICE2→partner) and Y-score (partner→ICE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Recombinational repair →	+0.092	+0.989	<.001	<.001	3	15
BONE	Regulation of heterochromatin organization →	+0.099	+0.917	.001	<.001	3	15
BLOOD_Myeloma	Protein sumoylation →	+0.073	+0.650	.001	.003	3	15
BONE	Mitotic G2/M transition checkpoint →	+0.118	+0.896	<.001	<.001	3	14
BONE	Nucleic acid transport →	+0.090	+0.541	<.001	<.001	3	14
BONE	RNA transport →	+0.090	+0.541	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,972 associations by consensus.

Recombinational repair by ICE2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →