ICE1

Across TCGA pan-cancer cohorts, ICE1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ICE1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ICE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ICE1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where ICE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.363	0.923	.008	13	view →
LUAD	OS	Median	III,IV	0.609	0.216	.023	8	view →
HNSC	DFS	Median	II,III,IV	0.795	0.522	.032	7	view →
GBM	DFS	Tertile	All	0.708	0.898	.021	2	view →
LSCC	DFS	Median	III,IV	1.000	0.867	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ICE1–PDAC (DFS)

Open the PDAC breakdown →