ICE1

Across TCGA patient cohorts, ICE1 mutation is significantly associated with the RNA expression of many other genes, with 6,597 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICE1-associated genes across cancer lineages are CD207, SFXN1, and CDKN3. Each is linked with ICE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ICE1-to-partner and partner-to-ICE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD207 grouped by ICE1-low versus ICE1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICE1→partner) and Y-score (partner→ICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD207 →	-1.428	-2.415	.003	.003	3	5
STAD	SFXN1 →	+0.554	+3.923	.001	<.001	3	5
STAD	CDKN3 →	+0.654	+2.597	.006	.005	3	4
STAD	AUNIP →	+0.656	+2.840	.001	.001	2	5
LUAD	CPAMD8 →	-1.099	-3.087	.001	<.001	3	4
UCEC	NDUFS4 →	+0.432	+1.525	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,597 associations by consensus.

CD207 by ICE1 expression — LUAD

Explore this box plot interactively →