ICE1

Across TCGA patient cohorts, ICE1 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICE1-associated genes across cancer lineages are ATM, MEK1, and p16_INK4a. Each is linked with ICE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ICE1-to-partner and partner-to-ICE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ICE1-low versus ICE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICE1→partner) and Y-score (partner→ICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.634	-1.765	<.001	<.001	3	3
UCEC	MEK1 →	+0.330	+2.058	<.001	<.001	3	3
LUSC	p16_INK4a →	+0.543	+2.823	.002	.034	3	2
LUSC	p38-MAPK →	+0.149	+3.000	.011	.033	3	2
LUSC	Stathmin →	+0.129	+1.883	.044	.031	3	2
LUSC	c-Met_pY1235 →	+0.070	+1.883	.036	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

ATM by ICE1 expression — UCEC

Explore this box plot interactively →