ICE1

Across TCGA cell cohorts, ICE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,458 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICE1-associated GO terms across cancer lineages are Establishment of mitotic sister chromatid cohesion, Centrosome cycle, and Centriole replication. Each is linked with ICE1 in more than 16 cancer types. Because this analysis shows association rather than direction, both ICE1-to-partner and partner-to-ICE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of mitotic sister chromatid cohesion grouped by ICE1-low versus ICE1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICE1→partner) and Y-score (partner→ICE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Establishment of mitotic sister chromatid cohesion →	+0.181	+1.185	<.001	<.001	3	17
OESOPHAGUS	Centrosome cycle →	+0.087	+0.973	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Centriole replication →	+0.108	+1.001	.002	.003	3	17
OESOPHAGUS	Microtubule organizing center organization →	+0.081	+0.927	.001	.003	3	17
UPPER_AERODIGESTIVE_TRACT	Establishment of RNA localization →	+0.125	+1.323	<.001	<.001	3	16
STOMACH	RNA export from nucleus →	+0.140	+1.133	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,458 associations by consensus.

Establishment of mitotic sister chromatid cohesion by ICE1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →