ICAM4

Across TCGA patient cohorts, ICAM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 743 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible ICAM4-associated GO terms across cancer lineages are Macrophage proliferation, Glial cell activation, and Regulation of pH. Each is linked with ICAM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM4-to-partner and partner-to-ICAM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophage proliferation grouped by ICAM4-low versus ICAM4-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM4→partner) and Y-score (partner→ICAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Macrophage proliferation →	+0.235	+0.981	<.001	<.001	3	1
SCLC	Glial cell activation →	+0.165	+1.045	<.001	<.001	3	1
SCLC	Regulation of pH →	+0.067	+0.677	.001	.003	3	1
SCLC	Phagocytosis →	+0.138	+1.026	<.001	<.001	3	1
SCLC	Phagocytosis, engulfment →	+0.163	+0.891	<.001	<.001	3	1
SCLC	Complement activation, classical pathway →	+0.265	+0.856	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 743 associations by consensus.

Macrophage proliferation by ICAM4 expression — SCLC

Explore this box plot interactively →