ICAM4

Across TCGA patient cohorts, ICAM4 mutation is significantly associated with the RNA expression of many other genes, with 142 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ICAM4-associated genes across cancer lineages are HDAC9-AS1, RNA5SP230, and MIR4290HG. Each is linked with ICAM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM4-to-partner and partner-to-ICAM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HDAC9-AS1 grouped by ICAM4-low versus ICAM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM4→partner) and Y-score (partner→ICAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HDAC9-AS1 →	+0.269	+3.463	.008	.003	3	2
SKCM	RNA5SP230 →	+0.183	+3.372	<.001	.005	3	2
COAD	MIR4290HG →	+0.033	+5.145	.006	.007	3	2
SKCM	GRAMD4P1 →	+0.078	+3.213	<.001	.007	3	2
UCEC	RNA5SP405 →	+0.509	+4.260	<.001	.007	3	1
UCEC	RNU6-1201P →	+0.911	+3.524	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 142 associations by consensus.

HDAC9-AS1 by ICAM4 expression — UCEC

Explore this box plot interactively →