ICAM4

Across TCGA cell cohorts, ICAM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,734 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ICAM4-associated GO terms across cancer lineages are Regulation of amyloid-beta clearance, Regulation of isotype switching to IgE isotypes, and Positive regulation of isotype switching to IgE isotypes. Each is linked with ICAM4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ICAM4-to-partner and partner-to-ICAM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of amyloid-beta clearance grouped by ICAM4-low versus ICAM4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM4→partner) and Y-score (partner→ICAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of amyloid-beta clearance →	+0.110	+0.937	.005	.008	3	7
BONE	Regulation of isotype switching to IgE isotypes →	-1.160	-2.061	<.001	<.001	3	6
BONE	Positive regulation of isotype switching to IgE isotypes →	-1.160	-2.061	<.001	<.001	3	6
SOFT_TISSUE	Negative regulation of mRNA metabolic process →	+0.057	+1.014	.001	.002	3	6
LARGE_INTESTINE	Regulation of amyloid-beta formation →	+0.074	+0.815	.001	.004	3	5
SOFT_TISSUE	5S class rRNA transcription by RNA polymerase III →	+0.088	+0.841	.004	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,734 associations by consensus.

Regulation of amyloid-beta clearance by ICAM4 expression — LARGE_INTESTINE

Explore this box plot interactively →