ICAM4

Across TCGA cell cohorts, ICAM4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICAM4-associated genes across cancer lineages are CST8, GAST, and CCDC190. Each is linked with ICAM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM4-to-partner and partner-to-ICAM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST8 grouped by ICAM4-low versus ICAM4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM4→partner) and Y-score (partner→ICAM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CST8 →	+0.031	+3.969	<.001	.009	3	1
BLOOD_Leukemia	GAST →	+0.091	+3.824	<.001	.001	3	1
BLOOD_Leukemia	CCDC190 →	+0.027	+3.926	.003	.003	3	1
BLOOD_Leukemia	SELENOV →	+0.062	+3.339	.002	.006	3	1
BLOOD_Leukemia	VSTM2B →	+0.070	+3.289	<.001	.009	3	1
BLOOD_Leukemia	FAM24A →	+0.040	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CST8 by ICAM4 expression — BLOOD_Leukemia

Explore this box plot interactively →