ICAM3

Across TCGA patient cohorts, ICAM3 mutation is significantly associated with the RNA expression of many other genes, with 991 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICAM3-associated genes across cancer lineages are RNU6-1022P, RN7SKP181, and DSCR4-IT1. Each is linked with ICAM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM3-to-partner and partner-to-ICAM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1022P grouped by ICAM3-low versus ICAM3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM3→partner) and Y-score (partner→ICAM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1022P →	+0.426	+6.763	<.001	<.001	3	2
HNSC	RN7SKP181 →	+0.129	+5.182	<.001	.007	3	2
HNSC	DSCR4-IT1 →	+0.343	+5.124	.004	.008	3	2
SKCM	MTND1P19 →	+0.069	+5.163	<.001	.002	3	2
HNSC	RNU4ATAC5P →	+0.299	+5.505	<.001	.004	3	2
HNSC	LINC01072 →	+0.276	+5.241	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 991 associations by consensus.

RNU6-1022P by ICAM3 expression — HNSC

Explore this box plot interactively →