ICAM3

Across TCGA patient cohorts, ICAM3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICAM3-associated genes across cancer lineages are p62 Lck ligand, eEF2, and eIF4E. Each is linked with ICAM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM3-to-partner and partner-to-ICAM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ICAM3-low versus ICAM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM3→partner) and Y-score (partner→ICAM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.401	+2.321	.014	.035	3	2
UCEC	eEF2 →	+0.465	+2.999	.009	.035	3	1
UCEC	eIF4E →	+0.211	+2.321	.046	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.302	-3.446	<.001	.005	3	1
UCEC	Ku80 →	+0.234	+2.335	.048	.020	3	1
UCEC	MEK1 →	+0.469	+2.321	.010	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

p62 Lck ligand by ICAM3 expression — UCEC

Explore this box plot interactively →