ICAM3

Across TCGA cell cohorts, ICAM3 mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ICAM3-associated genes across cancer lineages are GML, LYZL4, and OR1L3. Each is linked with ICAM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM3-to-partner and partner-to-ICAM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by ICAM3-low versus ICAM3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM3→partner) and Y-score (partner→ICAM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GML →	+0.147	+4.736	<.001	.009	3	2
BLOOD_Leukemia	LYZL4 →	+0.056	+4.375	<.001	<.001	3	2
BLOOD_Leukemia	OR1L3 →	+0.041	+3.013	.005	.001	3	2
BLOOD_Leukemia	VWC2L →	+0.010	+3.339	<.001	<.001	3	2
BLOOD_Leukemia	IGFL3 →	+0.030	+2.799	<.001	.005	3	2
BLOOD_Leukemia	DPRX →	+0.088	+3.797	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

GML by ICAM3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →