ICAM2

Across TCGA patient cohorts, ICAM2 mutation is significantly associated with the RNA expression of many other genes, with 1,460 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICAM2-associated genes across cancer lineages are TRAJ11, LACTB, and OXNAD1. Each is linked with ICAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM2-to-partner and partner-to-ICAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ11 grouped by ICAM2-low versus ICAM2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM2→partner) and Y-score (partner→ICAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAJ11 →	+0.585	+4.624	.001	.004	3	2
SKCM	LACTB →	+0.760	+3.465	.002	.003	3	2
SKCM	OXNAD1 →	+0.548	+3.491	.001	.002	3	2
SKCM	SAR1A →	+0.515	+3.465	.008	.003	3	2
UCEC	MYO19 →	+0.636	+2.724	<.001	.003	3	2
UCEC	RPL23AP82 →	+0.416	+2.592	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,460 associations by consensus.

TRAJ11 by ICAM2 expression — HNSC

Explore this box plot interactively →