ICAM2

Across TCGA patient cohorts, ICAM2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICAM2-associated genes across cancer lineages are mTOR, PTEN, and STAT3_pY705. Each is linked with ICAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ICAM2-to-partner and partner-to-ICAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by ICAM2-low versus ICAM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICAM2→partner) and Y-score (partner→ICAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.187	-2.459	.016	.020	3	1
UCEC	PTEN →	-0.500	-2.459	.009	.020	3	1
UCEC	STAT3_pY705 →	-0.306	-2.459	.015	.020	3	1
UCEC	Tuberin_pT1462 →	+0.325	+2.179	.003	.034	3	1
UCEC	CD49b →	-0.328	-2.980	.017	.036	2	1
UCEC	Cyclin-B1 →	+0.601	+2.459	.026	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

mTOR by ICAM2 expression — UCEC

Explore this box plot interactively →