ICA1L

Across TCGA pan-cancer cohorts, ICA1L mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ICA1L data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ICA1L mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ICA1L expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

GBM, LSCC, and UCEC are the cancer types where ICA1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.825	0.673	.003	10	view →
LSCC	OS	Tertile	II,III,IV	0.299	0.779	.013	6	view →
UCEC	DFS	Median	All	0.951	0.839	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ICA1L–GBM (DFS)

Open the GBM breakdown →