ICA1

Across TCGA pan-cancer cohorts, ICA1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ICA1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ICA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ICA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where ICA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.608	0.255	<.001	54	view →
LSCC	OS	Tertile	All	0.756	0.960	.001	36	view →
UCEC	DFS	Tertile	All	1.000	0.730	<.001	32	view →
CCRCC	DFS	Median	III,IV	0.105	0.928	.003	17	view →
LUAD	DFS	Quartile	II,III,IV	0.214	0.742	.010	12	view →
GBM	DFS	Median	All	0.441	0.295	.043	4	view →
HNSC	DFS	Median	III,IV	0.930	1.000	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ICA1–PDAC (DFS)

Open the PDAC breakdown →