ICA1

Across TCGA patient cohorts, ICA1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,169 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ICA1-associated proteins across cancer lineages are PICK1, ARFGEF3, and MISP3_S91. Each is linked with ICA1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ICA1-to-partner and partner-to-ICA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ICA1 versus PICK1 in BRCA, with a Pearson correlation of 0.67.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ICA1→partner) and Y-score (partner→ICA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PICK1 →	+0.599	+1.073	<.001	<.001	3	10
HNSC	ARFGEF3 →	+0.632	+1.120	<.001	<.001	3	6
UCEC	MISP3_S91 →	+0.769	+0.699	.003	.009	3	6
HNSC	PPP1R9A_S840 →	+1.510	+1.060	<.001	<.001	3	5
BRCA	PTPN1 →	-0.377	-0.802	<.001	.006	3	5
UCEC	MCF2L →	+0.496	+1.067	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,169 associations by consensus.

ICA1 vs PICK1 — BRCA

Explore this scatter interactively →