ICA1

Across TCGA patient cohorts, ICA1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,850 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ICA1-associated genes across cancer lineages are ARFGEF3, RAB19, and COBL. Each is linked with ICA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ICA1-to-partner and partner-to-ICA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ICA1 versus ARFGEF3 in BRCA, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICA1→partner) and Y-score (partner→ICA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARFGEF3 →	+1.071	+0.486	<.001	<.001	3	6
BRCA	RAB19 →	+0.857	+0.672	<.001	<.001	3	5
UCEC	COBL →	+1.190	+0.468	<.001	<.001	3	5
UCEC	RORC →	+1.253	+0.397	<.001	<.001	3	5
GBM	NT5DC1 →	+0.823	+0.405	<.001	<.001	3	5
LSCC	MYO5C →	+0.829	+0.482	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,850 associations by consensus.

ICA1 vs ARFGEF3 — BRCA

Explore this scatter interactively →