ICA1

Across TCGA patient cohorts, ICA1 mutation is significantly associated with the RNA expression of many other genes, with 3,461 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICA1-associated genes across cancer lineages are MIR4510, KIFBP, and AAGAB. Each is linked with ICA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ICA1-to-partner and partner-to-ICA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4510 grouped by ICA1-low versus ICA1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICA1→partner) and Y-score (partner→ICA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4510 →	+0.196	+4.342	<.001	.007	3	3
SKCM	KIFBP →	+0.519	+2.719	.007	.003	3	3
UCEC	AAGAB →	+0.513	+2.305	<.001	<.001	3	3
UCEC	BCCIP →	+0.429	+3.052	<.001	<.001	3	3
UCEC	PSMD9 →	+0.449	+2.679	<.001	<.001	3	3
UCEC	MRPS15 →	+0.421	+2.544	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,461 associations by consensus.

MIR4510 by ICA1 expression — CESC

Explore this box plot interactively →