ICA1

Across TCGA patient cohorts, ICA1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ICA1-associated genes across cancer lineages are PCNA, ATM, and Cyclin-B1. Each is linked with ICA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ICA1-to-partner and partner-to-ICA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ICA1-low versus ICA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ICA1→partner) and Y-score (partner→ICA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.177	+1.662	.020	.011	3	3
UCEC	ATM →	-0.460	-1.662	.004	.011	3	3
UCEC	Cyclin-B1 →	+0.718	+3.584	<.001	.002	3	3
UCEC	FoxM1 →	+0.184	+1.662	.044	.011	3	2
UCEC	MEK1 →	+0.491	+2.392	<.001	<.001	3	2
UCEC	ASNS →	+0.331	+1.807	.009	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PCNA by ICA1 expression — UCEC

Explore this box plot interactively →